John K Olynyk Selected Research

Hemochromatosis (Bronze Diabetes)

1/2022	Arthritis Prediction of Advanced Hepatic Fibrosis in HFE Hemochromatosis.
1/2021	Utility of Serum Biomarker Indices for Staging of Hepatic Fibrosis Before and After Venesection in Patients With Hemochromatosis Caused by Variants in HFE.
1/2021	Utility and limitations of Hepascore and transient elastography to detect advanced hepatic fibrosis in HFE hemochromatosis.
12/2019	Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis.
12/2017	Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial.
10/2017	Association of Transferrin Saturation With the Arthropathy of Hereditary Hemochromatosis.
4/2017	HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women.
1/2016	Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases.
7/2015	Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials.
4/2015	Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study.

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John K Olynyk Research Topics

Disease

39	Hemochromatosis (Bronze Diabetes) 01/2022 - 04/2002
25	Iron Overload 12/2017 - 03/2002
20	Fibrosis (Cirrhosis) 01/2022 - 10/2004
11	Liver Diseases (Liver Disease) 08/2021 - 03/2004
11	Non-alcoholic Fatty Liver Disease 12/2020 - 06/2006
11	Inflammation (Inflammations) 01/2017 - 04/2005
10	Hepatocellular Carcinoma (Hepatoma) 08/2021 - 06/2005
8	Neoplasms (Cancer) 01/2017 - 09/2008
6	Insulin Resistance 12/2020 - 03/2011
5	Arthritis (Polyarthritis) 01/2022 - 03/2006
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 10/2005
5	Chronic Renal Insufficiency 07/2017 - 04/2010
5	Anemia 01/2017 - 04/2005
3	Fatty Liver 12/2022 - 08/2010
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 07/2009
3	Hemorrhage 01/2022 - 11/2010
3	Hepatitis C 08/2021 - 04/2002
3	Necrosis 01/2021 - 08/2004
3	Liver Neoplasms (Liver Cancer) 01/2021 - 09/2016
3	Iron Deficiencies 01/2020 - 12/2009
3	Hyperferritinemia 12/2017 - 01/2011
3	Obesity 02/2016 - 01/2014
3	Colorectal Neoplasms (Colorectal Cancer) 01/2016 - 02/2010
3	Fatigue 08/2015 - 01/2008
3	Carcinogenesis 01/2013 - 02/2010
2	Infections 08/2021 - 01/2017
2	Hepatitis 01/2019 - 02/2016
2	Critical Illness (Critically Ill) 01/2018 - 11/2016
2	Joint Diseases (Joint Disease) 10/2017 - 01/2008
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2016 - 07/2009
2	Type 2 Diabetes Mellitus (MODY) 04/2015 - 09/2008
2	Chronic Disease (Chronic Diseases) 01/2014 - 04/2005
2	Chronic Hepatitis C 06/2006 - 05/2006
1	Rheumatoid Arthritis 01/2022
1	Chronic Hepatitis B 08/2021
1	Cholangiocarcinoma 01/2021
1	Alcoholic Fatty Liver 12/2020
1	Heart Diseases (Heart Disease) 12/2020
1	Dyslipidemias (Dyslipidemia) 01/2019
1	Cystic Fibrosis (Mucoviscidosis) 12/2017

Drug/Important Bio-Agent (IBA)

57	IronIBA 01/2021 - 04/2002
21	Ferritins (Ferritin)IBA 01/2021 - 02/2004
16	Transferrin (beta 2 Transferrin)IBA 01/2020 - 03/2002
8	CytokinesIBA 11/2017 - 08/2004
5	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2022 - 03/2011
4	HepcidinsIBA 01/2018 - 04/2005
4	Transferrin Receptors (Transferrin Receptor)IBA 01/2013 - 12/2009
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2016
3	AdiponectinIBA 12/2020 - 03/2011
3	LeptinIBA 12/2020 - 03/2011
3	EnzymesIBA 01/2019 - 09/2010
3	MetalsIBA 04/2016 - 12/2009
3	Choline (Choline Chloride)IBA 01/2016 - 08/2005
3	EthionineIBA 01/2016 - 08/2005
3	dimemorfan (AT 17)IBA 06/2014 - 05/2013
3	Glucose (Dextrose)FDA LinkGeneric 10/2013 - 08/2004
3	Proteins (Proteins, Gene)FDA Link 02/2013 - 01/2007
3	Dietary IronIBA 01/2013 - 04/2002
3	Interleukin-6 (Interleukin 6)IBA 01/2013 - 06/2005
2	Transaminases (Aminotransferases)IBA 01/2022 - 01/2008
2	InterferonsIBA 08/2021 - 11/2016
2	Thioacetamide (Thioacetamid)IBA 01/2021 - 01/2016
2	HDL CholesterolIBA 12/2020 - 03/2011
2	LipidsIBA 12/2020 - 10/2013
2	AdipokinesIBA 12/2020 - 03/2011
2	C-Reactive ProteinIBA 12/2020 - 05/2016
2	CholesterolIBA 12/2020 - 08/2010
2	Pentoxifylline (Trental)FDA LinkGeneric 07/2017 - 04/2010
2	HematinicsIBA 07/2017 - 01/2017
2	Erythropoietin FDA Link 07/2017 - 11/2016
2	F2-Isoprostanes (F2 Isoprostanes)IBA 08/2015 - 05/2015
2	Hemochromatosis ProteinIBA 04/2015 - 08/2012
2	metal transporting protein 1 (ferroportin)IBA 01/2013 - 01/2006
2	CollagenIBA 08/2012 - 10/2004
2	Alanine Transaminase (SGPT)IBA 03/2011 - 07/2009
2	Interferon-gamma (Interferon, gamma)IBA 12/2007 - 01/2007
1	Omega-6 Fatty Acids (Omega 6 Fatty Acids)IBA 12/2022
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2022
1	Dietary Fats (Dietary Fat)IBA 12/2022
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 12/2022
1	Methotrexate (Mexate)FDA LinkGeneric 01/2022
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022
1	Proton Pump InhibitorsIBA 01/2022
1	Ribavirin (Virazole)FDA LinkGeneric 08/2021
1	Antiviral Agents (Antivirals)IBA 08/2021
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2021
1	TransferasesIBA 01/2021
1	Triglycerides (Triacylglycerol)IBA 12/2020
1	lipoprotein cholesterolIBA 12/2020
1	LDL CholesterolIBA 12/2020
1	P-30 composite resin (P 30)IBA 01/2020
1	Keratin-7 (Cytokeratin 7)IBA 12/2017
1	Taurocholic Acid (Sodium Taurocholate)IBA 12/2017
1	Immune Checkpoint InhibitorsIBA 11/2017

Therapy/Procedure

9	Therapeutics 08/2021 - 05/2006
3	Liver Transplantation 08/2021 - 12/2014
3	Cell- and Tissue-Based Therapy (Cell Therapy) 02/2016 - 11/2005
2	Renal Dialysis (Hemodialysis) 01/2017 - 01/2011
2	Erythrocyte Transfusion 11/2016 - 04/2016
1	Drug Therapy (Chemotherapy) 01/2021